呵呵 隔了两个星期没有发paper过来 这个星期终于发过来了 不知道是这次的比较浅显 还是自己进步了
看起来竟然没有以前那么恼火了 甚至有点轻松 汗...
这次是han师姐发过来的 说起来实验室出了周师兄 就只认识她了...记得第一次去面试的时候,还和她聊了很久呢.她原来是清华化工系的,后来交叉保送到生物系,肯定黑强的,恩...还是老乡呢..四川咯～
感觉人很好的, 呵呵, 第二次面试的时候还问了她的email,结果一直都没联系过她.
不知道她地址的最后是OO还是00 (哈哈,这里也分不出来)
现在好了,刚好下次她回信的时候问点实验室的事情.
不说废话了,要看的就继续往下看吧,感觉这次写得还是一般了.
This week’s JC paper reports a novel angiogenic factor—Netrin-1, which is previously identified as a neural factor functioning in axonal guidance. Now in this paper, the authors demonstrated that Netrin-1 also functions as a vascular growth factor. They proved that Netrin-1 can stimulate proliferation, induce migration and promote adhesion of endothelial cells and vascular smooth muscle cells with a specific activity comparable to vascular endothelial growth factor and platelet-derived growth factor via a series of experiments. Furthermore, they also found Neogenin, the Netrin receptor, may be involved in mediating the Netrin-1 signaling in vascular smooth muscle cells, and the in vivo investigations confirmed the angiogenic effect of Netrin-1.
This discovery is really interesting and remarkable. Firstly, it again releases the phenomenon that different signal networks may share some factors, and here, Netrin-1 seems to function both in neural and vascular systems, while it’s believed that the two systems are distinct although they show some similarities in their development and organization. However, it is just the similarities between these two systems suggest and finally lead to the discovery of Netrin-1’s two different functions. Moreover, the difference of the two systems have determined the distinct functions of Netrin-1, which then suggests that there must be different receptors or mediators of Netrin-1 in the two signaling systems. Just as mentioned in the paper, some unidentified receptors of Netrin-1 in the signaling pathway are awaiting to be found. Secondly, also mentioned in the paper, since Netrin-1 has an angiogenic effect similar to its axonal attractive function, here comes the question that whether emphrins, semaphorins and slits will have an antiangiogenic effect as they act as a repulsive factor in neural growth. If they do, it will be of great help for scientist to have a better and deep understanding of these factors and find the possibly potential relationship between neural growth and vascular growth. Furthermore, once they do have antiangiogenic function, it will become possible to use them in tumor and other diseases therapy. Finally, the investigation that the angiogenic effect is augmented by mixing Netrin-1 and VEGF suggests that Netrin-1 and VEGF may share some down-stream receptors which may be activated by different factors. So, if emphrins, semaphorins and slits have antiangiogenic effects, and if this kind of synergistic phenomenon also exists, it will be very promising but great efforts still need to be put into when considering apply them into therapy.
看起来竟然没有以前那么恼火了 甚至有点轻松 汗...
这次是han师姐发过来的 说起来实验室出了周师兄 就只认识她了...记得第一次去面试的时候,还和她聊了很久呢.她原来是清华化工系的,后来交叉保送到生物系,肯定黑强的,恩...还是老乡呢..四川咯～
感觉人很好的, 呵呵, 第二次面试的时候还问了她的email,结果一直都没联系过她.
不知道她地址的最后是OO还是00 (哈哈,这里也分不出来)
现在好了,刚好下次她回信的时候问点实验室的事情.
不说废话了,要看的就继续往下看吧,感觉这次写得还是一般了.
This week’s JC paper reports a novel angiogenic factor—Netrin-1, which is previously identified as a neural factor functioning in axonal guidance. Now in this paper, the authors demonstrated that Netrin-1 also functions as a vascular growth factor. They proved that Netrin-1 can stimulate proliferation, induce migration and promote adhesion of endothelial cells and vascular smooth muscle cells with a specific activity comparable to vascular endothelial growth factor and platelet-derived growth factor via a series of experiments. Furthermore, they also found Neogenin, the Netrin receptor, may be involved in mediating the Netrin-1 signaling in vascular smooth muscle cells, and the in vivo investigations confirmed the angiogenic effect of Netrin-1.
This discovery is really interesting and remarkable. Firstly, it again releases the phenomenon that different signal networks may share some factors, and here, Netrin-1 seems to function both in neural and vascular systems, while it’s believed that the two systems are distinct although they show some similarities in their development and organization. However, it is just the similarities between these two systems suggest and finally lead to the discovery of Netrin-1’s two different functions. Moreover, the difference of the two systems have determined the distinct functions of Netrin-1, which then suggests that there must be different receptors or mediators of Netrin-1 in the two signaling systems. Just as mentioned in the paper, some unidentified receptors of Netrin-1 in the signaling pathway are awaiting to be found. Secondly, also mentioned in the paper, since Netrin-1 has an angiogenic effect similar to its axonal attractive function, here comes the question that whether emphrins, semaphorins and slits will have an antiangiogenic effect as they act as a repulsive factor in neural growth. If they do, it will be of great help for scientist to have a better and deep understanding of these factors and find the possibly potential relationship between neural growth and vascular growth. Furthermore, once they do have antiangiogenic function, it will become possible to use them in tumor and other diseases therapy. Finally, the investigation that the angiogenic effect is augmented by mixing Netrin-1 and VEGF suggests that Netrin-1 and VEGF may share some down-stream receptors which may be activated by different factors. So, if emphrins, semaphorins and slits have antiangiogenic effects, and if this kind of synergistic phenomenon also exists, it will be very promising but great efforts still need to be put into when considering apply them into therapy.
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